Why are glycoproteins modified by poly n acetyllactosamine glycoconjugates

These results therefore indicate that incubation at 21 degrees C causes the lamps to reside longer within the Golgi complex, and such longer residence allows lamps to acquire more polylactosaminoglycan.

These results also suggest that the time necessary for moving through the Golgi complex is a critical factor for poly-N-acetyllactosamine formation. Abstract The poly-N-acetyllactosamines on neutrophils and monocytes have been shown to serve as ligands for various selectins present on endothelial cells and platelets. These glycans have been suggested to be involved in biospecific interactions with selectins and other glycan-binding proteins. Moreover, the poly-N-acetyllactosamine chains in N-glycans have been found to promote tumor progression and metastasis.

Audette, Louis T. Khandekar, Robert A. Daines and John T. Lonsdale DOI: Hallberg and F. Nyberg DOI: Harnett, M. Harnett and O. Byron DOI: Betton DOI: Article Metrics PDF: Related Journals. Related eBooks. Journal Insight.